Inter Milan, languishing fifth from the bottom of the Serie A table, have the chance to start the long climb back in Turin against leaders Juventus on Saturday.
Inter grabbed a valuable point at Atalanta in midweek and coach Claudio Ranieri will be hoping for more of the same.
Juve, who are one point clear of Udinese and Lazio, maintained their unbeaten home record on Tuesday with a 2-1 victory over Fiorentina.
Juve midfielder Claudio Marchisio is enjoying being top of the table, a position the Turin club have not held since 2006.
"Its very nice being top of the table," Marchisio told Juventus Channel.
"Yet there are some regrets, as we dropped all those points along the way, so couldve been clearer in front."
Inter's Achilles heel this season has been penalties, conceding their fifth of the season against Atalanta.
Both clubs are set to field reserve goalkeepers with Gigi Buffon (collarbone) likely to miss for Juve and Julio Cesar (thigh) extremely doubtful for Inter.